# US 11,806,383 B2 · Topical compositions comprising pea proteins and polyphenols

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- Number: US 11,806,383 B2
- Document ID: US11806383B2
- Status: Granted
- Kind: B2
- Application number: 17/757,832
- Filed: 2020-12-21
- Published: 2023-02-09
- Granted: 2023-11-07
- Earliest claimed: 2019-12-23
- Assignees: Devintec Sagl
- Applicants: Devintec Sagl
- Inventors: Miguel Angel Alonso Cohen; Marco Di Fulvio
- Web page: https://patentgrep.com/patent/US11806383B2

## CPC

- A61K 38/168: {from plants}
- A61P 31/10: Antimycotics
- A61K 8/36: Carboxylic acids; Salts or anhydrides thereof
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K 31/37: Coumarins, e.g. psoralen
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/5777: {Theobroma, e.g. cocao or cocoa}
- A61K 36/742: {Coffea, e.g. coffee}
- A61K 38/01: Hydrolysed proteins; Derivatives thereof
- A61K 38/16: Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)}
- A61K 47/02: Inorganic compounds
- A61K 47/06: Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K 47/08: containing oxygen, {e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/42: Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34)
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61P 15/02: for disorders of the vagina
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/06: Antipsoriatics
- A61P 17/08: Antiseborrheics
- A61P 17/10: Anti-acne agents
- A61P 31/04: Antibacterial agents
- A61P 33/02: Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61Q 19/00: Preparations for care of the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The object of the invention is topical compositions comprising pea proteins and polyphenols and the use thereof for the treatment of local or generalised disorders caused by increased permeation of the natural epithelial barriers. Said disorders may be of bacterial, viral, inflammatory, allergic and/or fungal origin, or endogenous or idiopathic.

## Claims

### Claim 1

Method of treating localized disorders of bacterial, viral, inflammatory, allergic and/or fungal, endogenous, or idiopathic origin caused by permeation of the natural epithelial barriers, and disorders transferred from the epithelia to other systems in a subject in need thereof, said method comprising
administering a pharmaceutically effective amount of topical compositions comprising pea protein and polyphenols of the hydroxycinnamic and hydroxybenzoic acid families wherein the weight ratio of polyphenol to pea protein is from 0.4:1 to 1:10, in admixture with a suitable carrier to said subject, wherein the polyphenols are selected from chlorogenic acid and ellagic acid.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said localized disorders comprise atopic dermatitis, rosacea, psoriasis, contact dermatitis, dermatitis caused by exposure to sunlight, radiotherapy or chemotherapy, cutaneous candidiasis, fungal infections, vaginal candidiasis, polybacterial vaginitis, fungal and bacterial infections of the skin and mucous membranes, and infections caused by protozoa.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the polyphenol is ellagic acid.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the weight ratio of polyphenol to pea protein ranges from 1:1 to 1:6.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the weight ratio of polyphenol to pea protein is 1:1.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the compositions are in the form of ointments, lotions, creams, solutions, suspensions, gels, mouthwashes, medicated plasters or gauzes, powders, or pessaries.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the compositions further comprise moisturising, emollient, humectant, preservative, antioxidant, or pH-regulating additives.

### Claim 8 (depends on 7)

The method according to claim 7, wherein the additives are selected from lectin, lactic acid, sericin, poloxamers, carrageenan and arabinoxylan.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the additives are selected from lectin, poloxamers, carrageenan and arabinoxylan, each in concentrations by weight ranging from 0.1 to 2.5%.