Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and methods thereof
AssigneesIndustry-Academic Cooperation Foundation, Yonsei University, Research & Business Foundation Sungkyunkwan University
InventorsSung Jae Shin, Woo Sik Kim, Hong Min Kim, Kee Woong Kwon, Joo Heon Yoon, Won Jung Koh
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Abstract
The present invention relates to a method for inducing differentiation of bone marrow cells into myeloid-derived suppressor cells (MDSCs) by treating the bone marrow cells with a toll-like receptor agonist (TLR agonist) or type I interferon, or for inducing dendritic cells from the MDSCs.
Claims15
A method for producing myeloid-derived suppressor cells (MDSCs), comprising:
- a step of treating bone marrow cells with a toll-like receptor agonist (TLR agonist) or type I interferon, to induce differentiation into myeloid-derived suppressor cells,
- wherein the toll-like receptor agonist is at least one of toll-like receptor 7 agonist and toll-like receptor 9 agonist,
- wherein the myeloid-derived suppressor cells comprise MDSCs having phenotype PDCA-1+, and
- wherein the toll-like receptor agonist or the type I interferon is applied at the initiation time of bone marrow cell differentiation, and then is applied one or more times within 3 days after the initiation of differentiation.
A method for preventing or treating an immune disease, the method comprising treating bone marrow cells with a toll-like receptor agonist (TLR agonist) or type 1 interferon to induce differentiation into myeloid-derived suppressor cells, and administering the myeloid-derived suppressor cells to a subject in need thereof,
- wherein the toll-like receptor agonist is at least one of toll-like receptor 7 agonist and toll-like receptor 9 agonist, and
- wherein the myeloid-derived suppressor cells comprise MDSCs having phenotype PDCA-1+.
Dependencies are inferred from the claim text.