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AssigneeCelera Corporation
InventorsSteve Ruben, Tao He, Candy Lee, Karen Van Orden, Paul Moore
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Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
A method of inhibiting proliferation of pancreatic cancer cells, the method comprising contacting the pancreatic cancer cells with an oligonucleotide that selectively hybridizes to a SLC5A6 mRNA molecule thereby inhibiting proliferation of the pancreatic cancer cells, wherein the sequence of the oligonucleotide comprises a sequence selected from the group consisting of:
A method of inhibiting proliferation of pancreatic cancer cells, the method comprising contacting the pancreatic cancer cells with an oligonucleotide that selectively hybridizes to a SLC5A6 mRNA molecule thereby inhibiting proliferation of the pancreatic cancer cells, wherein the sequence of the oligonucleotide consists of a sequence selected from the group consisting of:
Dependencies are inferred from the claim text.