Lysophosphatidic acid derivative
AssigneesMitsubishi Tanabe Pharma Corporation, Osaka University
InventorsMaiko Hamada, Yuki Arai, Shuhei Yamakoshi, Hiroko Wada, Kazufumi Otsuki, Hiroaki Shitama, Nobuyuki Takakura
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Abstract
The present invention aims to provide a compound acting as a specific agonist for LPA4 receptors, and a pharmaceutical composition containing the compound. The present invention relates to a novel lysophosphatidic acid derivative having an agonistic action on LPA4 receptors and useful for the prophylaxis and/or treatment of diseases associated with angiogenesis abnormalities involving LPA4 receptors, diseases associated with vascular disorders, or the symptoms associated therewith, and a pharmaceutical composition containing the derivative.
Claims16
A compound represented by the following formula (I)
- wherein
- X is oxygen,
- Y is oxygen, —O—CH2—, or —CH2—O—,
- Q is —C(═O)—,
- R1 is a group represented by the following formula (A-2)
- wherein ring B is cycloalkane or benzene, R7 in the number of n are each independently
- halogen,
- cyano,
- optionally substituted alkyl,
- optionally substituted cycloalkyl,
- optionally substituted alkoxy, or
- an optionally substituted aromatic hydrocarbon group, and
- n is an integer of 0-5,
- L1 is R6—, —R6O—, —OR6—, —R6NH—, or —NHR6—,
- R6 is an optionally substituted alkylene,
- R2 is hydrogen or alkyl, and
- one of R3 and R4 is hydrogen or optionally substituted alkyl, and the other is bonded to R5 to form, together with a carbon atom bonded to R3 and R4, a carbon bonded to R2, and a nitrogen atom bonded to R5, an optionally substituted cyclic amine,
- or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.