Methods for extraction, processing, and purification of a selected family of target compounds from cannabis

A method for separating, recovering, and purifying a cannabidiolic acid-amine salt (CBDA-amine salt) from an organic solvent solution comprising a mixture of cannabinoids, said method comprising:

• providing an organic solvent solution containing therein a complex mixture of cannabinoids;
• assaying the organic solvent solution to determine a first concentration of CBDA therein;
• adding a volume of an alkane solvent to the organic solvent solution and commingling therewith to adjust the first CBDA concentration to a target concentration value selected from a range of target concentrations, thereby producing a solvent-solubilized solution;
• adding an amine to the solvent-solubilized solution and commingling therewith to precipitate therefrom a CBDA-amine salt, wherein said amine is selected from a group consisting of:
• a tertiary amine selected from one of triethylamine, tripropylamine, tributyl amine, and quinine, or
• a diamine selected from one of N,N,N-trimethylethylenediamine, N,N,N,N-tetramethylethylenediamine, 4-aminomethylpiperidine, 1,5-diazabicyclooctane (DABCO), 4 dimethylaminopyridine (DMAP), 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), 1,8-diazabicycloundec-7-ene (DBU), and dimethylpiperazine, or
• a secondary amine selected from one of diisopropylethylamine (Hunig's base), diethylamine, N-isopropylcyclohexylamine, and 2,2,6,6-tertamethylpiperidine, or
• an amino alcohol selected from one of piperidineethanol and N,N-dimethylethanolamine, or
• an amino ether selected from one of morpholine and N-methylmorpholine, or cyclohexylamine;
• separating the precipitated CBDA-amine salt from the solvent-solubilized solution;
• washing the recovered CBDA-amine salt at least once with said selected alkane solvent;
• and
• drying the washed CBDA-amine salt to produce the CBDA-amine salt.