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US 11,801,294 B2Granted
Method of enhancing innate immune responses against a tumor comprising administering lymphocytic choriomeningitis virus (LCMV)
AssigneeAbalos Therapeutics GmbH
InventorsKarl Sebastian Lang, Halime Kalkavan
Life of this patent
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Abstract
The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.
Claims13
A method of enhancing an innate immune response in a subject bearing a malignant tumor, comprising:
- administering to the subject a lymphocytic choriomeningitis virus (LCMV) that increases secretion of interferon-α by innate (congenital) immune cells, thereby activating the innate (congenital) immune cells,
- wherein the sequences of the L- and S-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile L- and S-ribonucleic acid sequences.
Dependencies are inferred from the claim text.