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AssigneeCapricor, Inc.
InventorsLuis Rodriguez-Borlado, Houman Hemmati, Jennifer L Johnson, Kiel A. Peck, Rachel R. Smith, Linda Marban
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The present invention relates to a method of treating a chemical injury of the eye, in particular alkali burn of the cornea, as well as ocular GVHD and similar inflammatory ocular conditions, with extracellular vesicles, in particular exosomes obtained from human cardiospheres or cardiosphere-derived cells. The present invention also provides a formulation comprising extracellular vesicles, in particular exosomes obtained from human cardiospheres or cardiosphere-derived cells, for subconjunctival or topical administration to the eye in the treatment of a chemical injury of the eye, in particular alkali burn of the cornea, as well as ocular GVHD and similar inflammatory ocular conditions.
A method of treating Sjogren's syndrome in a human in need thereof comprising administering a therapeutically effective amount of extracellular vesicles produced from cardiosphere-derived cells to said human in need thereof to effectively treat the Sjogren's syndrome in said human in need thereof.
Dependencies are inferred from the claim text.