Nasogastric device and method

A method of treating an esophageal stricture, comprising:

• providing a nasogastric device, including:
• a first flexible tube having a distal end configured to be threaded through a nose of a patient, down an esophagus and into a stomach;
• a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of said first flexible tube, the distal end of said second tube configured to terminate inside the esophagus;
• an inflatable balloon configured around said first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes;
• a third flexible tube in fluid communication with said inflatable balloon configured to inflate said inflatable balloon;
• and a fourth flexible tube having a distal end portion communicating with an exterior portion of said inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules into a space exterior to first inflatable balloon;
• and positioning said nasogastric device utilizing visualized radiopaque markers at an esophageal stricture;
• injecting said therapeutic molecules through said fourth flexible tube;
• and inflating the inflatable balloon against said esophageal stricture and simultaneously delivering said therapeutic molecules to esophageal tissue adjacent the inflatable balloon;
• wherein an elastomeric sleeve at least partially surrounds said inflatable balloon, and wherein said inflating of said inflatable balloon forces said therapeutic molecules through perforations of elastomeric sleeve to esophageal tissue adjacent to the device.