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US 11,795,497 B2Granted
Enrichment of nucleic acid targets
AssigneeQuantum-Si Incorporated
InventorsAndrea Marziali, Milenko Despotovic, Joel Pel
Life of this patent
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Abstract
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
Claims16
A method of sequencing a target molecule comprising:
- (a) isolating the target molecule from a sample, wherein the isolating comprises
- (i) applying a time-varying driving field to the sample in the presence of an affinity matrix comprising immobilized probes, the probes having a binding affinity for the target molecule;
- (ii) applying a periodically varying, mobility-altering field that modifies the binding affinity;
- wherein application of the time-varying driving field and the periodically varying, mobility-altering field isolates the target molecule from the sample;
- and
- (b) subjecting the target molecule to sequencing.
3 more elements
A method of sequencing a target molecule comprising:
- (a) isolating a target molecule from a sample using scodaphoresis;
- and
- (b) subjecting the target molecule to sequencing.
Dependencies are inferred from the claim text.