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US 11,795,238 B2Granted
Anti-idiotype antibodies targeting anti-CD70 chimeric antigen receptor
AssigneeCrispr Therapeutics AG
InventorsLalit Kumar, Mary-Lee Dequeant
Life of this patent
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Abstract
High affinity antibodies capable of binding to a single-chain variable fragment (scFv) of anti-CD70 antibody, for example, the scFv expressed on cell surface as a portion of a chimeric antigen receptor (CAR). Also provided herein are methods for producing such anti-scFv antibodies and methods of using the antibodies disclosed herein for detecting, for example, T cells expressing an anti-CD70 CAR that comprise the scFv as an extracellular domain.
Claims20
An isolated antibody, which binds a single-chain variable fragment (scFv) consisting of the amino acid sequence of SEQ ID NO:
- 1, wherein the antibody comprises heavy chain complementary determining region (CDR)1, CDR2, and CDR3 comprising the amino acid sequences of SEQ ID NOs:9-11, respectively, and light chain CDR1, CDR2, and CDR3 comprising the amino acid sequences SEQ ID NOs:15-17, respectively, following the Kabat approach.
Dependencies are inferred from the claim text.