# US 11,793,980 B2 · Intestinal attachment device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,793,980 B2 - Document ID: US11793980B2 - Status: Granted - Kind: B2 - Application number: 17/007,122 - Filed: 2020-08-31 - Published: 2021-03-04 - Granted: 2023-10-24 - Earliest claimed: 2019-08-31 - Assignees: Celero Systems, Inc. - Applicants: Celero Systems, Inc. - Inventors: Benjamin D. Pless; Daniel Bacher - Web page: https://patentgrep.com/patent/US11793980B2 ## CPC - A61M 31/00: Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) - A61M 31/002: {Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50)} - A61B 5/42: {Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems (A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence)} - A61B 5/4839: {combined with drug delivery} - A61B 5/6861: {Capsules, e.g. for swallowing or implanting} - A61B 5/6873: {Intestine} - A61B 5/6882: {Anchoring means} - A61M 2205/18: with alarm - A61M 2205/32: with radio-opaque indicia - A61M 2205/3303: Using a biosensor - A61M 2205/3306: Optical measuring means - A61M 2205/3584: using modem, internet or Bluetooth® - A61M 2210/1042: Alimentary tract (A61M2210/0618 takes precedence) - A61M 2230/04: Heartbeat characteristics, e.g. ECG, blood pressure modulation - A61M 2230/42: Rate - A61M 2230/50: Temperature - A61M 2230/63: Motion, e.g. physical activity - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An intestinal attachment device is provided that includes an ingestible housing with a chamber having disposed therein a low-profile ribbon with a head that serves as a single attachment area for an anchor sized and configured to attach to the mucosal surface of an intestine. A disposable material is also disposed within the chamber and at least partially surrounds the ribbon. An anchor is disposed within the housing and is attached to the head of the low-profile ribbon. The anchor has a constrained and a non-constrained state and is sized and configured to attach to the mucosal surface of the intestine. The anchor is at least partially surrounded by a dissolvable material. ## Claims ### Claim 1 An intestinal attachment device comprising: an ingestible housing having an internal chamber; a low-profile ribbon comprising a controller comprising an electrical circuit that is configured to actuate therapeutic agent release on a fixed schedule or in response to detection of a physiological event, the ribbon disposed within the chamber and having a head and a trailing portion extending from the head, the head serving as a single attachment area for an anchor sized and configured to attach to the mucosal surface of an intestine; a dissolvable material disposed within the chamber and at least partially surrounding the ribbon; a fixation device disposed within the housing; the anchor disposed within the housing and attached to the head of the low-profile ribbon, the anchor having a constrained state and a non-constrained state and sized and configured to attach to the mucosal surface of the intestine; and another dissolvable material at least partially surrounding the anchor. ### Claim 2 (depends on 1) The intestinal attachment device of claim 1, wherein the fixation device is a mucoadhesive pad defining a well and the anchor is disposed in the well. ### Claim 3 (depends on 1) The intestinal attachment device of claim 1, further comprising an enteric coating at least partially surrounding the chamber. ### Claim 4 (depends on 1) The intestinal attachment device of claim 1, further comprising a tether, the anchor attached to the head of the ribbon via the tether. ### Claim 5 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises the therapeutic agent. ### Claim 6 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises a sensor. ### Claim 7 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises rigid sections and flexible sections, wherein the electrical circuit, a sensor, or combinations thereof are mounted on the rigid sections of the ribbon. ### Claim 8 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises: a drug dispenser comprising the therapeutic agent; at least one sensor configured to detect at least one physiological parameter that has a threshold value or range indicative of a medical condition; and the controller being operatively coupled to the drug dispenser and the at least one sensor, the controller configured to receive a signal detected by the least one sensor of the at least one physiological parameter to actuate release of the therapeutic agent from the drug dispenser into the intestine of the patient upon a determination that the at least one physiological parameter falls outside the threshold value or range for the at least one physiological parameter. ### Claim 9 (depends on 8) The intestinal attachment device of claim 8, wherein the anchor serves as the drug dispenser. ### Claim 10 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises: a drug dispenser comprising the therapeutic agent, the therapeutic agent comprising an opioid antidote; at least one sensor configured to detect at least one physiological parameter that has a threshold value or range indicative of an opioid overdose; and the controller being operatively coupled to the drug dispenser and the least one sensor, the controller configured to receive a signal detected by the least one sensor of the at least one physiological parameter to actuate release of the opioid antidote from the drug dispenser into the intestine of the patient upon a determination that the at least one physiological parameter falls outside the threshold value or range for the at least one physiological parameter indicating that an opioid overdose has been detected. ### Claim 11 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises: a drug dispenser comprising the therapeutic agent, the therapeutic agent comprising an opioid antidote; an accelerometer configured to sense motion within the intestine; and the controller operatively being coupled to the drug dispenser and the accelerometer, the controller configured to receive motion sensing data from the accelerometer and estimate a respiratory rate of the patient based on the motion sensing data and to actuate release of the opioid antidote from the drug dispenser into the intestine of the patient upon a determination that the respiratory rate falls outside a threshold value or range indicating that an opioid overdose has been detected. ### Claim 12 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises: a drug dispenser comprising the therapeutic agent, the therapeutic agent comprising an opioid antidote; a photoplethysmography (PPG) sensor configured to sense PPG data; the controller being operatively coupled to the drug dispenser and the PPG sensor, the controller configured to receive PPG sensing data from the PPG sensor and estimate a respiratory rate of the patient based on the PPG sensing data and to actuate release of the opioid antidote from the drug dispenser into the intestine of the patient upon a determination that the respiratory rate falls outside a threshold value or range indicating that an opioid overdose has been detected. ### Claim 13 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises a radio-opaque strip. ### Claim 14 (depends on 1) The intestinal attachment device of claim 1, wherein the anchor is biodegradable. ### Claim 15 (depends on 1) The intestinal attachment device of claim 1, wherein the anchor is biodegradable and is pre-loaded with the therapeutic agent that is released once the anchor biodegrades. ### Claim 16 (depends on 1) The intestinal attachment device of claim 1, wherein the ribbon comprises a wireless communication module to communicate with an external device. ### Claim 17 (depends on 1) The intestinal attachment device of claim 1, wherein the therapeutic agent is disposed within the anchor.