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US 11,793,891 B2Granted
Fluorescein formulations and kits
AssigneeOpus Life Sciences, LLC
InventorsPatrick H. Witham, William Stringer
Life of this patent
Estimating the term…
Abstract
Compositions comprising a fluorescein component and benoxinate component and the corresponding uses of these compositions are described herein. These compositions have improved storage life and the fluorescein component and/or benoxinate component minimally degrade after 12 to 18 months of storage.
Claims23
A kit comprising:
- an aqueous formulation comprising from about 50 mg/mL to about 300 mg/mL fluorescein sodium, wherein the formulation has a pH of from about 8 to about 10;
- and
- a glass vial holding the aqueous formulation, where the glass vial comprises a shoulder portion that interconnects a neck portion and a body portion, wherein the shoulder portion includes a frustoconical shoulder wall that extends toward the body portion at a transition angle (β) of at least 120°,
- wherein the aqueous formulation has a dissolved silicon concentration upon filling the glass vial (Si0w), and a dissolved silicon concentration after storage in the glass vial at 60° C. for 10 weeks (Si10w), wherein Si10w/Si0w is from 1 to 1.6;
- the aqueous formulation has a dissolved boron concentration upon filing the glass vial (B0w), and a dissolved boron concentration after storage in the glass vial at 60° C. for 10 weeks (B10w), wherein B10w/B0w is from 1 to 1.9;
- Si10w is less than 14 mg/L;
- and
- B10w is less than 2.2 mg/L.
5 more elements
Dependencies are inferred from the claim text.