Monolithic composition for dual-rate release with high drug loading
AssigneeMatripharm International Inc.
InventorTien Canh Le
Life of this patent
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Abstract
The present document describes a process for the preparation of a low functionalization polysaccharide having carboxyl groups, comprising a) swelling of a polysaccharide granule in boiling water or a water/polyol mixture, to obtain a swollen polysaccharide; b) partial gelatinization of said swollen polysaccharide in an alkaline solvent mixture of water and alcohol and/or polyol, to obtain a partially gelatinized polysaccharide; and c) partial functionalization of said partially gelatinized polysaccharide with a functionalizing agent, to obtain the low functionalization polysaccharide.
Claims13
A process for the preparation of a low functionalization polysaccharide having carboxyl groups, comprising:
- a) swelling of a polysaccharide granule in boiling water or a boiling water/polyol mixture, to obtain a swollen polysaccharide;
- b) partial gelatinization of said swollen polysaccharide in an alkaline solvent mixture of water and alcohol and/or polyol to obtain a suspension of a partially gelatinized polysaccharide;
- c) low functionalization of said partially gelatinized polysaccharide in said suspension with a functionalizing agent under alkaline conditions, to obtain said functionalized polysaccharide, wherein said functionalized polysaccharide has a degree of substitution of from about 0.1 to about 0.3,
- wherein said polyol is ethylene glycol, propylene glycol, glycerol, sorbitol or combinations thereof.
Dependencies are inferred from the claim text.