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US 11,793,877 B2Granted
Controlled drug release from electrospun fibers
AssigneeRensselaer Polytechnic Institute
InventorsAnthony R. D'Amato, Nicholas Schaub, Andrew Sante Fiumara, Paul Michael Troiano, Jesus Cardenas, Ryan J. Gilbert
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Abstract
Embodiments of the invention relate generally to electrospun fibers and, more particularly, to the controlled release of an active pharmaceutical ingredient (API) from electrospun fiber scaffolds (EFSs).
Claims5
A drug delivery system comprising:
- a first electrospun poly-L-lactic acid (PLLA) fiber scaffold (EFS) having a first crystallinity percentage;
- a second PLLA EFS having a second crystallinity percentage different than that of the first PLLA EFS;
- and at least one active pharmaceutical ingredient (API), wherein the at least one API is released from the first PLLA EFS at a first rate and the at least one API is released from the second PLLA EFS at a second rate different than the first release rate upon administration of the drug delivery system to an individual,
- wherein the first PLLA EFS is heat treated at a first temperature and the second PLLA EFS is heat treated at a second temperature, and
- wherein the first temperature is between about 50° C. and about 60° C. and the second temperature is at least 80° C.
2 more elements
Dependencies are inferred from the claim text.