Vault complexes for cytokine delivery
AssigneesThe Regents of the University of California, The United States Government as represented by the Department of Veterans Affairs
InventorsLeonard H. Rome, Valerie Ann Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Abstract
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
Claims14
A method of delivering a cytokine to a cell or a subject, which comprises administering a nucleic acid encoding a fusion protein comprising a major vault protein interaction domain (mINT) fused to a cytokine to the cell or the subject, said nucleic acid comprising a cytokine encoding sequence and a mINT encoding sequence that encodes SEQ ID NO:8 or SEQ ID NO:9.
A method of delivering a CCL-21 chemokine to a cell or a subject, which comprises administering a nucleic acid encoding a fusion protein comprising a major vault protein interaction domain (mINT) fused to SEQ ID NO:
- 2 or the protein product encoded by the nucleic acid.
A method of delivering a CCL-21 chemokine to a cell or a subject, which comprises administering a nucleic acid encoding a fusion protein comprising a major vault protein interaction domain (mINT) comprising SEQ ID NO:8 fused to the CCL-21 chemokine or the protein product encoded by the nucleic acid.
Dependencies are inferred from the claim text.