TFPI inhibitors and methods of use
AssigneeTakeda Pharmaceutical Company Limited
InventorsMichael Dockal, Rudolf Hartmann, Markus Fries, Friedrich Scheiflinger, Hartmut Ehrlich, Ulrich Reineke, Frank Osterkamp, Thomas Polakowski
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Abstract
The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, an identify a TFPI-binding compound.
Claims22
A method for treating a subject suffering from a blood coagulation disorder, the method comprising administering to the subject a peptide comprising (a) the amino acid sequence having at least 80% identity to SYYKWH[CA-Moo-RDLKGTFTC]VWVKF (SEQ ID NO:
- 1334) or (b) a variant of SEQ ID NO:
- 1334, wherein the variant comprises one or two amino acid substitution(s), deletion(s) or insertion(s).
Dependencies are inferred from the claim text.