Use of additives, copolymers, and dopants for optical stability of analyte sensing components
AssigneeSenseonics, Incorporated
InventorsRyan DeSousa, Robert Atwood, Philip Huffstetler, Joon Chatterjee, Sanat Mohanty
Life of this patent
Estimating the term…
Abstract
A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more optical signal stabilizing additives in an environment of the sensor.
Claims39
A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
- an analyte indicator having an opacity;
- and
- one or more optical signal stabilizing additives, wherein the one or more optical signal stabilizing additives maintain the opacity of the analyte indicator over time.
A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
- an analyte indicator having an opacity;
- and
- one or more optical signal stabilizing additives, wherein the one or more optical signal stabilizing additives maintain the opacity of the analyte indicator over time, wherein the one or more optical signal stabilizing additives include one or more dithio-containing dopants ranging in alkyl chain length from 2-34 carbon atoms.
A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:
- applying an analyte indicator having an opacity to a sensor such that the applied analyte indicator covers at least a portion of a sensor housing, sensor substrate, or sensor electrode, wherein the analyte indicator comprises one or more optical signal stabilizing additives, and the one or more optical signal stabilizing additives maintain the opacity of the analyte indicator over time.
Dependencies are inferred from the claim text.