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US 11,788,962 B2Granted
Method and apparatus for rapid detection of bacterial contamination
AssigneeUniversity of Maryland, Baltimore County
InventorsGovind Rao, Yordan Kostov, Mustafa Al-Adhami, Chandrasekhar Gurramkonda
Life of this patent
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Abstract
A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.
Claims10
A microfluidic cassette comprising:
- an inlet channel that splits into a sample channel and a sample-derived negative control channel, wherein the sample channel is communicatively connected to a sample chamber and the sample-derived negative control channel is communicatively connected to at least one sample-derived negative control chamber, wherein the inlet channel comprises an inlet port upstream of the split, a first port downstream of the sample chamber, and a second port downstream of the sample-derived negative control chamber(s), wherein the microfluidic cassette comprises a filter along the sample-derived negative control channel positioned between the split and the sample-derived negative control chamber(s), and wherein the microfluidic cassette further comprises a light barrier positioned between the sample chamber and the sample-derived negative control chamber(s).
Dependencies are inferred from the claim text.