Parathyroid hormone receptor 1 (PTH1R) antibodies and uses thereof
AssigneeXoma (US) LLC
InventorsRaphael D. Levy, Hassan Issafras, Agnes Choppin Holmes, Kirk W. Johnson, Amer M. Mirza, Daniel H. Bedinger, Rachel A. Hunt, Toshihiko Takeuchi, Kiranjit Kaur Ahluwalia, Robyn Cotter
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Abstract
The present disclosure relates, in general, human antibodies against human parathyroid hormone receptor 1 (PTH1R) and methods of use of such antibodies in the treatment of cancer, Humoral Hypercalcemia of Malignancy (HHM), or Primary Hyperparathyroidism (PHPT) and Secondary Hyperparathyroidism (SHPT) and cachexia.
Claims24
An antibody that binds parathyroid hormone receptor 1 (PTH1 R) with an affinity Kd of 2×10−8 M or less, wherein the antibody comprises (a) a heavy chain CDR1 amino acid sequence set forth in SEQ ID NOs:
- 45;
- (b) a heavy chain CDR2 amino acid sequence set forth in SEQ ID NOs:
- 46;
- (c) a heavy chain CDR3 amino acid sequence set forth SEQ ID NOs:
- 47;
- (d) a light chain CDR1 amino acid sequence set forth in SEQ ID NOs:
- 149;
- (e) a light chain CDR2 amino acid sequence set forth in SEQ ID NOs:
- 150;
- and
- (f) a light chain CDR3 amino acid sequence set forth in SEQ ID NOs:
- 151, and wherein the antibody is an IgG4 antibody.
Dependencies are inferred from the claim text.