Triaryl phosphine ligands, preparation method therefor, and use in catalyzing coupling reactions
AssigneeDongguan Stephen Catalyst Co., Ltd.
InventorsJicheng Shi, Fabin Zhou
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Abstract
Triaryl phosphine ligands, as shown in general formulae Ia and Ib, or a mixture thereof, and a preparation method therefor. The invention addresses the deficiencies of biaryl phosphine ligands invented by Buchwald et al. Also provided are a triaryl phosphine coordinated palladium complex, a system composed of triaryl phosphine ligand and a palladium salt or complex, and a use of the triaryl phosphine coordinated palladium complex in catalysing organic reactions, in particular a use in catalysis of coupling reactions involving (pseudo)halogenated aromatic hydrocarbon as substrate.
Claims4
Triaryl phosphine ligands is selected from the group consisting of Ia and Ib:
- wherein,
- Ar is selected from 4-methoxyphenyl, 4-(dimethylamino)phenyl, 2-methoxyphenyl, 2-(dimethylamino)phenyl, 2,6-dimethoxyphenyl, 2,6-diisopropoxyphenyl, 2,6-bis(dimethylamino)phenyl, 2-methoxy-6-(dimethylamino)phenyl, or 2-methoxy-1-naphthyl;
- R1 is selected from H, (C1-C6)alkyl, —O(C1-C6)alkoxy or —N(C1-C6)2 dialkylamino;
- R2 and R3 are each independently selected from (C1-C10) alkyl, (C3-C10) cycloalkyl, (5-11 membered) heterocycloalkyl, (C6-C20) aryl, (C4-C20) hetero aryl or —CH2(C6-C10) arylmethylene, here (C3-C10) cycloalkyl, (5-11 membered) heterocycloalkyl, (C6-C20) aryl, (C4-C20) heteroaryl and —CH2(C6-C10)arylene groups can have 1 to 3 independently selected from (C1-C6)alkyl or —O(C1-C6)alkoxy, —N(C1-C6)2 substituents of dialkylamino groups, where the heteroatoms in the heteroaryl group are selected from O, N or S atom.
Dependencies are inferred from the claim text.