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US 11,787,826 B2Granted
Hydrocarbyl tin complex of alkynyl phosphonic acid with antitumor activity and application thereof
AssigneeZhejiang Hongsheng Intellectual Property Operation Co., Ltd.
InventorsZhongda Duan, Jiande Jin
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Abstract
Hydrocarbyl tin complexs of alkynyl phosphonic acid with antitumor activity and their application are provided. Tests are conducted to evaluate activity, showing that the provided complexs have much stronger activity than cisplatin. The provided hydrocarbyl tin complexs can be potential candidate as a clinical antitumor drug.
Claims7
A hydrocarbyl tin complex of alkynyl phosphonic acid with antitumor activity, characterized by having the following structure:
- wherein, R1 is selected from the group consisting of n-butyl, t-butyl, phenyl, benzyl, p-chlorobenzyl and dimethylbenzyl;
- and R2 is a randomly substituted alkyl, aryl and heteroaryl wherein the alkyl, aryl or heteroaryl is substituted with 1 to 5 substituents selected from the group consisting of nitryl, cyano group, and trifluoromethyl, n is an integer from 2.
Dependencies are inferred from the claim text.