Carboxylic diarythiazepineamines as mixed mu- and delta-opioid receptor agonists

A compound having the structure:

• wherein
• R1 is —H or -(alkyl);
• R2 is —(C3-C20 alkyl)-CO2H or —(C3-C20 alkyl)-CO2-(alkyl);
• R3 is —H or -(alkyl);
• R4, R5, R6 and R7 are each independently —H, —Cl, —Br, —F, —I, —CN, —CF3, —OCF3, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), —NH2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —OH, —OAc, —O—C(O) (alkyl), —O-(alkyl), —O-(alkylaryl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —S(O)-(alkyl), —S(O)-(aryl), —S(O)-(heteroaryl), —SO2-(alkyl), —SO2-(aryl), or —SO2-(heteroaryl);
• R8, R9, —R10 and —R11 are each independently —H, —Cl, —Br, —F, —I, —CN, —CF3, —OCF3, -(alkyl), -(aryl), -(heteroaryl) -(alkenyl), -(alkynyl), —NH2, —NH-(alkyl), —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —OH, —OAc, —O—C(O)(alkyl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), —S-(heteroaryl), —S(O)-(alkyl), —S(O)-(aryl), —S(O)-(heteroaryl), —SO2-(alkyl), —SO2-(aryl), or —SO2-(heteroaryl);
• wherein when R2 is —(C3-6 alkyl)-CO2H, then one of R5 or R6 is -(alkynyl) or —S-(alkyl), or R5 and R6 are each independently —Cl, —Br, —F, or —I,
• wherein when R2 is —(C3-6 alkyl)-CO2-(alkyl), then one of R5 or R6 is -(alkynyl), or R5 and R6 are each independently —Cl, —Br, —F, or —I, and
• wherein when R1 is —CH3, R3, R4, R6, R7, R8, R9, —R10 and —R11 are each —H, and R5 is Cl, then R2 is other than —(CH2)7CO2H, —(CH2)10CO2H, —CH(CH3)(CH2)5CO2H or —(CH2)2CH(CH3)(CH2)3CO2H, and
• wherein when R1 is —CH3, R3, R4, R6, R7, R8, R9, —R10 and —R11 are each —H, and R5 is SCH3, then R2 is other than —(CH2)6CO2H,
• or a pharmaceutically acceptable salt or ester thereof.