Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (PTFE) by mussel-inspired modification and RGD/heparin grafting
AssigneeWisconsin Alumni Research Foundation
InventorsLih-Sheng Turng, Hao-yang Mi
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Abstract
Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces.
Claims7
A modified hydrophobic substrate comprising a substrate comprising a hydrophobic surface, a first layer comprising dopamine disposed on the hydrophobic surface, a second layer comprising a polymer comprising a terminal amine disposed on the first layer, and a third layer comprising at least one biomolecule covalently bonded to the terminal amine of the polymer of the second layer, wherein the at least one biomolecule is selected from the group consisting of a cell adhesion molecule and an anticoagulant.
Dependencies are inferred from the claim text.