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US 11,786,587 B2Granted
Composition of subunit dengue vaccine
AssigneeNational Cheng Kung University
InventorsYee-Shin Lin, Trai-Ming Yeh, Yung-Chun Chuang, Chia-Yi Yu, Hsin-Wei Chen, Shu-Wen Wan, Shu-Ying Wang, Tzong-Shiann Ho, Dar-Bin Shieh
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Abstract
The present invention relates to a composition of subunit dengue vaccine comprising a fusion protein of conjugating or connecting delta C nonstructural protein 1 (NS1ΔC or truncated NS1ΔC) to at least one polypeptides of NS3c (or truncated NS3c) and/or consensus envelope protein domain III (cEDIII), thereby enhancing better protection against DENV challenge and alleviating associated pathological effects.
Claims9
An immunogenic composition [of subunit dengue vaccine], comprising:
- a fusion protein of truncated NS1 polypeptide of SEQ ID NOs:
- 5 and truncated NS3c polypeptide of SEQ ID NOs:
- 6, and optionally together with one or more pharmaceutically acceptable carriers and/or adjuvants.
Dependencies are inferred from the claim text.