Back to results
US 11,786,569 B2Granted
Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsGreg M. Delgoffe, Dayana Rivadeneira, Padmavathi Sampath, Stephen H. Thorne
Life of this patent
Estimating the term…
Abstract
Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF-1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
Claims20
A recombinant oncolytic virus, comprising:
- a nucleic acid molecule encoding one or more metabolic modulating proteins, wherein the one or more metabolic modulating proteins is leptin, adiponectin, apelin, or chemerin.
Dependencies are inferred from the claim text.