Methods of treating neurofibromatosis with perillyl alcohol
AssigneeUniversity of Southern California
InventorThomas Chen
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Abstract
The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.
Claims9
A method of inhibiting or decreasing Ras level and/or activity in a cell, comprising administering to the cell perillyl alcohol, an iso-perillyl alcohol, or a combination thereof,
- further comprising administering temozolomide, dimethyl celecoxib, or rolipram.
A method of inhibiting or decreasing Ras level and/or activity in a subject, comprising administering to the subject an effective amount of perillyl alcohol, an iso-perillyl alcohol, or a combination thereof,
- further comprising administering temozolomide, dimethyl celecoxib, or rolipram.
A method of inhibiting or decreasing Ras level and/or activity in a cell or in a subject, comprising administering to the cell perillyl alcohol, an iso-perillyl alcohol, or a combination thereof,
- further comprising administering a compound selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, simvastatin, rosuvastatin and prostratin.
Dependencies are inferred from the claim text.