Transmucosal psychoactive alkaloid composition and preparation thereof

A process for obtaining an oral transmucosal psychoactive alkaloid composition, the process comprising:

• extracting a psychoactive alkaloid from a dried powdered psychoactive alkaloid source using a first solvent acidified to a pH lower than 3.5, to obtain a psychoactive alkaloid liquid;
• adding a base to the psychoactive alkaloid liquid to bring its pH to 3.5-4.5;
• evaporating the first solvent from the psychoactive alkaloid liquid to obtain a psychoactive alkaloid extract with more dephosphorylated psychoactive alkaloid than phosphorylated psychoactive alkaloid;
• treating multiple bed volumes of the psychoactive alkaloid extract in aqueous form with one bed volume of a resinous material to obtain an adsorbed psychoactive alkaloid;
• eluting the adsorbed psychoactive alkaloid using a second solvent different from the first solvent to obtain a purified psychoactive alkaloid solution, wherein the second solvent is water, an organic solvent or a combination thereof, under basic, acidic or neutral pH;
• evaporating the second solvent from the purified psychoactive alkaloid solution to obtain a purified form of the psychoactive alkaloid extract;
• and
• mixing the purified form of the psychoactive alkaloid extract with a mucoadhesive polymer and a carrier to obtain the oral transmucosal psychoactive alkaloid composition.