Nanoparticles

A thermosensitive lipid nanoparticle comprising:

• (i) at least one phospholipid selected from the group consisting of a phosphatidylcholine, a phosphatidylethanolamine, a phosphatidylglycerol, a phosphatidylserine, a phosphatidic acid, a phosphatidylinositol, and a sphingolipid;
• (ii) at least one lysolipid selected from the group consisting of a monoacylphosphatidylcholine, a monoacylphosphatidylglycerol, a monoacylphosphatidylinositol, and a monoacylphosphatidyl-ethanolamine;
• (iii) at least one phospholipid comprising a hydrophilic polymer,
• wherein the hydrophilic polymer comprises one or more selected from the group consisting of polyethylene glycol, polyvinylpyrolidine, polylactic acid, polyglycolic acid, copolymers of polylactic acid and polyglycolic acid, polyvinyl alcohols, polyvinylpyrrolidone, dextrans, and oligosaccharides;
• and
• (iv) at least one structural lipid selected from the group consisting of a gadolinium (III) 2,2′,2″-(10-(2-((6-((2-(dioctadecylamino)-2-oxoethyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (Gd.DOTA.AHX.DSA);
• or gadolinium (III) 2,2′,2″(10-(2-((8-((2-(dioctadecylamino)-2-oxoethyl)amino)-8-oxooctyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (Gd.DOTA.AOC.DSA);
• wherein (i) phospholipid:(ii) lysolipid:(iii) phospholipid comprising a hydrophilic polymer:(iv) Gd.DOTA.AHX.DSA, or Gd.DOTA.AOC.DSA are present in the thermosensitive lipid nanoparticle in a molar ratio of about (i) 30-90:(ii) 2-15:(iii) 4-10:(iv) 20-30;
• wherein the thermosensitive lipid nanoparticle has improved thermal stability and a sharp temperature release profile at a temperature range of 39.0° C.-43.0° C.