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US 11,785,976 B2Granted
Protein hydrolysates and methods of making same
AssigneeMead Johnson Nutrition Company
InventorsTeartse Tim Lambers, Cindy van Bommel, Zihua Ao, Anja Wittke, Kelly Alina Dingess, Kasper Hettinga
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Abstract
The present disclosure generally relates to methods of preparing protein hydrolysates for use in pediatric nutritional compositions. Specifically, alpha-, beta- and/or kappa casein enriched casein, acid casein or caseinates can be hydrolyzed with proteases such as trypsin (trypsin-like), chymotrypsin (chymotrypsin-like), pepsin and/or plasmin to produce a hydrolysate that is close to the peptide composition of human breast milk.
Claims20
A nutritional composition comprising:
- a milk protein preparation, the milk protein preparation comprising:
- a casein, acid casein or caseinate,
- wherein the milk protein preparation is hydrolyzed with at least two proteases selected from the group consisting of:
- trypsin;
- proteolytic enzymes that cleave peptide bonds following a positively charged amino acid;
- chymotrypsin;
- proteolytic enzymes that cleave peptide bonds following a tyrosine, phenylalanine or tryptophan residue;
- pepsin;
- and plasmin to form a protein hydrolysate,
- wherein the protein hydrolysate comprises alpha-casein peptides, beta-casein peptides, and kappa-casein peptides,
- wherein the beta-casein peptides in the protein hydrolysate comprise about 25% to about 60% of the total peptides in the nutritional composition, and
- wherein the kappa-casein peptides in the protein hydrolysate comprise about 1% to about 10% of the total peptides in the nutritional composition.
9 more elements
A nutritional composition comprising:
- a protein hydrolysate, the protein hydrolysate comprising alpha-casein peptides, beta-casein peptides, and kappa-casein peptides,
- wherein the beta-casein peptides in the protein hydrolysate comprise about 25% to about 60% of the total peptides in the nutritional composition, and
- wherein the kappa-casein peptides in the protein hydrolysate comprise about 1% to about 10% of the total peptides in the nutritional composition.
Dependencies are inferred from the claim text.