Rubella virus spike construct
AssigneesJudith Stuermer, Institut Virion \ Serion GmbH
InventorsThomas Schumacher, Hugo Arends
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Abstract
The Rubella Virus Spike construct comprises at least one E1 component and one E2 component, which are linked together. The E1 component consists of the El envelope protein, whose C-terminal transmembrane region and intravirional domain are removed and whose N-terminus comprises the ectodomain of the El envelope protein. The E2 component consists of the E2 envelope protein whose transmembrane regions and intravirional domain removed and whose C-terminus comprising the ectodomain of the E2 envelope protein. The C-terminus of the E2 component is connected to the N-terminus of the E1 component by direct fusion or by means of a linker to form an E1-E2 fusion protein.
Claims20
Rubella virus antigen, wherein it is a rubella virus E1-E2 envelope protein complex construct comprising
- at least one E1 component and one E2 component which are linked,
- wherein the E1 component consists of the E1 envelope protein whose C-terminal transmembrane region and intravirion are removed and whose N-terminus comprises the ectodomain of the E1 envelope protein,
- and wherein the E2 component consists of the E2 envelope protein whose transmembrane regions and intravirion are removed and whose N-terminus comprises the ectodomain of the E2 envelope protein,
- and wherein the C-terminus of the E2 component is connected to the N-terminus of the E1 component directly or by means of linkers.
Dependencies are inferred from the claim text.