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US 11,780,801 B2Granted
Methods of synthesis of (1R,2R,5R)-5-amino-2-methyl-cyclohexanol hydrochloride and intermediates useful therein
AssigneeCelgene Corporation
InventorsTerrence Joseph Connolly, Hon-Wah Man
Life of this patent
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Abstract
Provided herein are methods and intermediates for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.
Claims12
A method for preparing a compound of formula (9):
- the method comprising contacting a compound of formula (8):
- with a mixture of a reducing agent, a chiral auxiliary and a Lewis acid in a solvent, followed by treatment with an oxidant in the presence of a base.
Dependencies are inferred from the claim text.