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US 11,779,657 B2Granted
Compositions and methods for mitochondrial genome editing
AssigneesCity of Hope, The Regents of the University of California
InventorsJohn Burnett, Anh Pham
Life of this patent
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Abstract
Compositions and methods for mitochondria genome editing are provided. Also provided are methods for treating mitochondrial disorders by the disclosed compositions.
Claims18
A composition comprising a nucleic acid comprising a mitochondrial import sequence and a single-guide RNA (sgRNA) sequence,
- wherein said mitochondrial import sequence comprises a D loop and a F loop,
- wherein said D loop is within a tetraloop or stemloop 2 and said F loop is 3′ to stemloop 3 of a nucleic acid sequence within the sgRNA that is complementary to a mitochondrial DNA (mtDNA) target sequence.
Dependencies are inferred from the claim text.