Parasite vaccine
AssigneesThe Walter and Eliza Hall Institute of Medical Research, The University of Melbourne
InventorsChris Tonkin, Alessandro Uboldi, Malcolm McConville, Martin Blume
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Abstract
The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.
Claims22
An isolated mutant protozoan Toxoplasma gondii parasite wherein the mutant parasite is attenuated when grown or cultured in glucose-containing medium but not attenuated when grown or cultured in glucose-free medium and wherein said attenuation results from the uncontrolled accumulation of starch-like amylopectin stores when grown in glucose-containing medium, wherein the mutant parasite comprises an inactivating mutation of the trehalose-6-phosphate synthase/trehalose-6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma (ΔTPS/TPP) comprising a sequence SEQ ID NO:1 or SEQ ID NO:3.
Dependencies are inferred from the claim text.