Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction

A method of treating hot flashes in a subject diagnosed with cancer, the method comprising administering to the subject a compound of formula (I)

• or a pharmaceutically acceptable salt, ester or prodrug thereof,
• wherein
• each K is independently N or CH, wherein at least two K's are N;
• Q, T, U, and V are independently selected from H or R;
• W, X, Y and Z are independently selected from H, R, F, Cl, Br, I, OH, OR or CO2H;
• each R is independently selected from straight chain or branched alkyl groups;
• R1 and R2 are independently H or R;
• and
• R3, R4, R5 and R6 are independently selected from H or R, thereby treating hot flashes in the subject.