Bisphenol ether derivatives and methods for using the same

A method for modulating androgen receptor activity, comprising:

• administering to a patient in need thereof a compound having the following structure (I):
• or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein:
• wherein:
• X is —C(R3R4)—;
• R1 and R2 are each independently H, halogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —OH, —OR5, —O(C1-C6)alkyl, —OC(═O)R13, C1-C10 acyl, —S(O)0-2R5, —NO2, —CN, —NH2, —NHR5, —N(R5R6), —CO2H, CO2R14, or CONR5R6;
• R3 and R4 are each independently H, C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl;
• R5 and R6 is each independently H, C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl;
• R7 is each independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, aminocarbonyl, C1-C10 alkylcarbonyl, C2-C10 alkenylcarbonyl, C2-C10 alkynylcarbonyl, alkylaminocarbonyl, C2-C10 alkenylaminocarbonyl, or C2-C10 alkynylaminocarbonyl;
• R13 is each independently C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl;
• R14 is each independently H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl;
• L1 is hydroxyl or —OC(═O)R13;
• L2 and L3 are each independently H, halogen, hydroxyl, —OC(═O)R13, —OC1-C10 alkyl, —OC2-C10 alkenyl, —OC2-C10 alkynyl, —OR15,—SR5, —NR5R6, —O(C1-C10 acyl), —OC1-C10 alkylene-(—O—C1-C10 alkyl)p, —OC1-C10 alkylene-(—O—C2-C10 alkynyl)p, —OC1-C10 alkylene-(—O—C2-C10 alkenyl)p, —OC2-C10 alkenylene-(—O—C1-C10 alkyl)p, —OC2-C10 alkenylene-(—O—C2-C10 alkenyl)p, —OC2-C10 alkenylene-(—O—C2-C10 alkynyl)p, —OC2-C10 alkynylene-(—O—C1-C10 alkyl)p, —OC2-C10 alkynylene-(—O—C1-C10 alkenyl)p, —OC2-C10 alkynylene-(—O—C2-C10 alkynyl)p, carbocyclyl, aryl, heterocyclyl, or heteroaryl;
• wherein at least one of L2 and L3 is a hydroxyl, —OC(═O)R13, substituted or unsubstituted carbocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heteroaryl;
• R15 is each independently selected from the group consisting of
• wherein aa is a naturally occurring amino acid side chain and n is an integer from 1 to 200;
• and
• a, b and c, are each independently 0, 1, 2, 3, 4, 5, or 6;
• m and n are each independently 0,1, 2, 3, or 4;
• and
• p is 1, 2, 3, or 4.