Crosslinking agent, preparation process and uses thereof, hydrogel and biodegradable cryogel comprising crosslinking agent
AssigneeNational Taiwan University
InventorsShan-hui Hsu, Tzu-Wei Lin
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a crosslinking agent, the preparation process and uses thereof, a hydrogel and a biodegradable cryogel including the crosslinking agent.
Claims8
A biodegradable cryogel obtained by reacting a crosslinking agent comprising a plurality of difunctional polyurethane nanoparticles wherein each of the difunctional polyurethane nanoparticles has a plurality of aldehyde groups with a polymer having amine groups and being placed at a temperature of −17° C. to −25° C.;
- wherein the polymer having amine groups is chitosan or its derivatives;
- wherein the biodegradable cryogel upon subcutaneous injection, becomes covered with immune cells on and around it, and wherein said immune cells comprise macrophages, wherein the ratio of M2 macrophages to M1 macrophages is more than three to about 3.5.
A hydrogel obtained by reacting by reacting a crosslinking agent comprising a plurality of difunctional polyurethane nanoparticles wherein each of the difunctional polyurethane nanoparticles has a plurality of aldehyde groups with a polymer having amine groups;
- wherein the polymer having amine groups is chitosan or its derivatives;
- wherein the hydrogel has a storage modulus and a loss modulus, and the storage modulus and the loss modulus are measured by damage-healing cycles at strain of 500% for damage and at strain of 1% for healing;
- upon subcutaneous injection, becomes covered with immune cells on and around it, and wherein said immune cells comprise macrophages, wherein the ratio of M2 macrophages to M1 macrophages was more than three to about 3.5.
Dependencies are inferred from the claim text.