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US 11,773,142 B2Granted
Recombinant adenoviruses and uses thereof
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsDan H. Barouch, Peter Abbink, Mark Justin Iampietro, Menzo J. E. Havenga
Life of this patent
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Abstract
Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
Claims26
A recombinant adenovirus comprising:
- (I) a nucleotide sequence encoding a hexon protein, wherein:
- (a) the nucleotide sequence encoding the hexon protein has at least 93% sequence identity over the entire sequence of SEQ ID NO:
- 56;
- or
- (b) the hexon protein comprises 99% or greater sequence identity over the entire amino acid sequence of SEQ ID NO:
- 160;
- (II) a nucleotide sequence encoding a short fiber protein, a long fiber protein, and/or a penton protein, wherein:
- (a) the nucleotide sequence encoding the short fiber protein has at least 85% identity to the nucleotide sequence of SEQ ID NO:
- 19;
- (b) the short fiber protein has at least 85% identity to the amino acid sequence of SEQ ID NO:
- 123;
- (c) the nucleotide sequence encoding the long fiber protein has at least 90% identity to the nucleotide sequence of SEQ ID NO:
- 42;
- (d) the long fiber protein has at least 90% identity to the amino acid sequence of SEQ ID NO:
- 146;
- (e) the nucleotide sequence encoding the penton protein has at least 95% sequence identity over the entire sequence of SEQ ID NO:
- 108, and/or
- (f) the penton protein comprises 96% or greater sequence identity over the entire amino acid sequence of SEQ ID NO:
- 212;
- and
- (III) a deletion in or of the E1, E2, and/or E3 region.
18 more elements
Dependencies are inferred from the claim text.