US 11,773,109 B2 · Composition for hardening soft tissue

Abstract

The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.

Claims5

Dependent claims

A compound or a pharmaceutically acceptable salt or hydrate thereof, wherein the compound is selected from the group consisting of the following compounds:

1) Cyclohexylmethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;
2) 3-(tert-butoxy)-3-oxopropyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;
3) 2-fluorobenzyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;
and
4) 2-(2-ethoxyethoxy)ethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/925,043Filed 9 Jul 2020 · division

Priority

KR 10-2016-010289512 Aug 2016

Published

US 2020/0339601 A129 Oct 2020

Granted

3 Oct 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 499/21
Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:…
C07D 499/46
Compounds with an amino radical acylated by carboxylic acids, attached in position 6: with acyclic hydrocarbon radicals or such radicals…
C07D 499/06
Preparation: by forming the ring or condensed ring systems
C40B 30/06
Methods of screening libraries: by measuring effects on living organisms, tissues or cells

Family

PCT/KR2017/008743Parent of this division · filed 11 Aug 2017

US 2020/0339601 A1Pre-grant publication · published 29 Oct 2020

Application16/325,073Parent of this division

US 10,745,417 B2Parent of this division

US 2019/0315770 A1Published application

US 11,773,109 B2This patent

From the US filing history. Foreign family members aren’t listed.

Composition for hardening soft tissue

Life of this patent

Composition for hardening soft tissue

Life of this patent

Abstract

Claims5