Methods and compounds for treating disorders

A method of treating synovial sarcoma in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound having the structure of Formula I:

• A-L-B Formula I
• wherein
• L is a linker;
• B is a degradation moiety, which has the structure of Formula A-1:
• wherein
• Y1 is
• each of R3 and R4 is, independently, H, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• q is 0, 1, 2, 3, or 4;
• and
• each R2 is, independently, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 heteroalkenyl, hydroxyl, —SH, or optionally substituted amino;
• A has the structure of Formula E-a:
• where
• R22 is H, optionally substituted C1-C6 alkyl, or optionally substituted C1-C6 heteroalkyl;
• R23 is H, halogen, optionally substituted C1-C6 alkyl, or optionally substituted C6-C10 aryl;
• s′ is 0, 1, or 2;
• each R24 is, independently, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 heteroalkenyl, hydroxyl, —SH, or optionally substituted amino, or two R24 combine with the carbon atoms to which they are attached to form an optionally substituted C6-C10 aryl or optionally substituted C2-C9 heteroaryl;
• s is 0, 1, 2, 3, or 4;
• and
• each R25 is, independently, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C3-C10 carbocyclyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 heteroalkenyl, hydroxyl, —SH, or optionally substituted amino, or a pharmaceutically acceptable salt thereof.