Methods and compositions for treating microbial inflammation
AssigneesVanderbilt University, The United States AS Represented By the Department of Veterans Affairs
InventorsJack Jacek Hawiger, Jozef Zienkiewicz, Ruth Ann Veach, Yan Liu, Lukasz Wylezinski
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Abstract
Disclosed are compositions and methods for treating microbial inflammation including its end-stage sepsis and conditions associated with the microbial inflammation such as thrombocytopenia and hypoglycogenemia. In one aspect, the compositions and methods disclosed herein can also be used to enhance clearance of microbes from infected tissues, organs, or systems in a subject. Also disclosed herein are compositions and methods for reducing levels of stress responsible transcription factors and metabolic transcription factors in a cell in a subject with microbial inflammation.
Claims6
A method of treating microbial inflammation in a subject comprising administering to the subject a therapeutically effective amount of an anti-microbial agent and a composition comprising a Nuclear Transport Modifier (NTM);
- wherein the microbial inflammation is caused by a bacterial infection;
- wherein the bacteria causing the bacterial infection is not Bacillus anthracis;
- and wherein the NTM comprises the sequence as set forth in SEQ ID NO:
- 2, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, or SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.