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US 11,769,654 B2Granted
Two dimensional MSMS
AssigneeMicromass UK Limited
InventorsKeith Richardson, Jason Lee Wildgoose
Life of this patent
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Abstract
A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.
Claims18
A method of mass spectrometry comprising:
- performing a plurality of cycles of operation during a single experimental run in which a mixture including a plurality of standards is analysed, wherein each cycle comprises:
- mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses capable of being transmitted therefrom is varied with time;
- mass analysing ions so as to obtain mass spectral data;
- and
- performing a calibration procedure that comprises:
- processing the mass spectral data using peak detection;
- matching detected mass peaks to expected mass peaks for the standards;
- and
- constructing a mapping or calibration relationship between the mass to charge ratio values for the standards and the time of transmission of the standards by the mass separator or mass filter.
6 more elements
A method of mass spectrometry comprising:
- performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises:
- mass selectively transmitting precursor ions of a range of masses through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is varied such that different ranges of masses are capable of being transmitted therefrom at different times within the cycle;
- and
- mass analysing ion;
- wherein the width of the range of masses that is capable of being transmitted by the mass separator or filter at any given time is varied during one or more of the cycles and/or between different ones of said cycles.
2 more elements
A method of mass spectrometry comprising:
- performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises:
- mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses capable of being transmitted therefrom at any given time is scanned or stepped with time over a mass window;
- and
- mass analysing ion;
- wherein the mass window is different for different ones of said cycles.
2 more elements
Dependencies are inferred from the claim text.