Method and process for predicting and analyzing patient cohort response, progression, and survival

A system, comprising:

• a computer including a processing device, the processing device configured to:
• receive, via an interactive portal displayed on a display device operatively coupled to a computer, a user selection of a dataset representing a cohort of patients, the dataset stored in a patient data store, wherein each patient in the cohort of patients has been diagnosed with one or more cancers, and wherein the dataset comprises clinical information relating to each of the patients and biomarker information relating to a tumor specimen of each of the patients;
• identify a plurality of pre-defined notebooks, each of the pre-defined notebooks comprising a template that may be displayed in the interactive portal as one or more cells, each cell fillable with one of a plurality of preconfigured elements selected from analytics, models, visualizations, or reportings for implementing a specific type of disease progression analysis, each preconfigured element corresponding to programming code useable to provide the associated analytics, models, visualizations, or reportings;
• generate a notebook interface comprising a new notebook interface element for creating a new notebook and a plurality of other notebook user interface elements, each of the other notebook user interface elements configured to launch a pre-defined notebook;
• receive, via the interactive portal, a user selection of one of the notebook user interface elements;
• in response to user selection of the new notebook interface element, generate a notebook generation interface including one or more draggable user interface elements corresponding to the preconfigured elements, wherein dragging one of the user interface elements into a cell of the notebook populates the cell with code for generating an associated analytic, model, visualization, or reporting, the notebook generation interface also for receiving user selections of one or more of the preconfigured elements to specify a new notebook, and storing the new notebook as a user-defined notebook for subsequent use;
• in response to user selection of one of the other notebook user interface elements:
• model a subset of the dataset according to a statistical model of the user-selected notebook or analyzing a subset of the dataset according to an analysis of the user-selected notebook without requiring user selection of the subset of the dataset or additional coding or recoding by the user
• apply the visualizations or reportings to the modeled or analyzed dataset to provide results to the user via the interactive portal, wherein the visualizations and reportings include representations of each cell of the notebook corresponding to the user-selected notebook user interface element;
• and
• enable the user to modify the notebook, including enabling the user to modify code associated with one or more of the cells including modifying an input for one of the disease progression statistical models or analyses and generating one or more draggable user interface elements corresponding to the preconfigured elements, wherein dragging one of the user interface elements into a cell of the notebook populates the cell with code for generating an associated analytic, model, visualization, or reporting.

A non-transitory computer-readable storage medium having stored thereon program code instructions that, when executed by a processor, cause the processor to:

• receive, via an interactive portal displayed on a display device operatively coupled to a computer, a user selection of a dataset representing a cohort of patients, the dataset stored in a patient data store, wherein each patient in the cohort of patients has been diagnosed with one or more cancers, and wherein the dataset comprises clinical information relating to each of the patients and biomarker information relating to a tumor specimen of each of the patients;
• identify a plurality of pre-defined notebooks, each of the pre-defined notebooks comprising a template that may be displayed in the interactive portal as one or more cells, each cell fillable with one of a plurality of preconfigured elements selected from analytics, models, visualizations, or reportings for implementing a specific type of disease progression analysis, each preconfigured element corresponding to programming code useable to provide the associated analytics, models, visualizations, or reportings;
• generate a notebook interface comprising a new notebook interface element for creating a new notebook and a plurality of other notebook user interface elements, each of the other notebook user interface elements configured to launch a pre-defined notebook;
• receive, via the interactive portal, a user selection of one of the notebook user interface elements;
• in response to user selection of the new notebook interface element, generate a notebook generation interface including one or more draggable user interface elements corresponding to the preconfigured elements, wherein dragging one of the user interface elements into a cell of the notebook populates the cell with code for generating an associated analytic, model, visualization, or reporting, the notebook generation interface also for receiving user selections of one or more of the preconfigured elements to specify a new notebook, and storing the new notebook as a user-defined notebook for subsequent use;
• in response to user selection of one of the other notebook interface elements:
• model a subset of the dataset according to a statistical model of the user-selected notebook or analyzing a subset of the dataset according to an analysis of the user-selected notebook without requiring user selection of the subset of the dataset or additional coding or recoding by the user
• apply the visualizations or reportings to the modeled or analyzed dataset to provide results to the user via the interactive portal, wherein the visualizations and reportings include representations of each cell of the notebook corresponding to the user-selected notebook user interface element;
• and
• enable the user to modify the notebook, including enabling the user to modify code associated with one or more of the cells including modifying an input for one of the disease progression statistical models or analyses and generating one or more draggable user interface elements corresponding to the preconfigured elements, wherein dragging one of the user interface elements into a cell of the notebook populates the cell with code for generating an associated analytic, model, visualization, or reporting.