Methods and materials for identifying and treating cancers having elevated levels of phosphorylated ubiquitin
AssigneeMayo Foundation for Medical Education and Research
InventorsZhenkun Lou, Min Deng
Life of this patent
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Abstract
This document provides methods and materials involved in identifying mammals (e.g., humans) having cancer cells with an elevated level of phosphorylated Ub polypeptides (e.g., an elevated level of Y59 phosphorylated Ub polypeptides). For example, methods and materials for detecting the presence of cancer cells having an elevated level of Y59 phosphorylated Ub polypeptides are provided.
Claims14
A method for treating cancer, wherein said method comprises:
- (a) identifying a mammal as having cancer cells comprising an elevated level of Y59 phosphorylated Ub polypeptides, and
- (b) administering a tyrosine kinase inhibitor to said mammal, thereby reducing the number of said cancer cells within said mammal, wherein said tyrosine kinase inhibitor is an epidermal growth factor receptor (EGFR) inhibitor or is a fibroblast growth factor receptor (FGFR) inhibitor.
A method for treating cancer, wherein said method comprises administering a tyrosine kinase inhibitor to a mammal identified as having cancer cells comprising an elevated level of Y59 phosphorylated Ub polypeptides, thereby reducing the number of said cancer cells within said mammal, wherein said tyrosine kinase inhibitor is an epidermal growth factor receptor (EGFR) inhibitor or is a fibroblast growth factor receptor (FGFR) inhibitor.
Dependencies are inferred from the claim text.