Method of detecting anti-Ri in a subject with a previous streptococcal infection
AssigneeQuest Diagnostics Investments Incorporated
InventorsStanley J. Naides, Joanna Popov
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Abstract
Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of ELAVL2, ELAVL3, ELAVL4, Nova-1, Nova-2, Cdr1, Cdr2; and Cdr3. The presence of such autoantibodies is indicative of a positive diagosis for a post-streptococcal disease such as PANDAS, post-GABHS glomerulonephritis, rheumatic fever, autism and Syndenham's chorea.
Claims7
A detection method comprising:
- (a) obtaining a fluid sample from a subject previously diagnosed with a Streptococcal infection and suspected of having pediatric autoimmune neuropsychiatric disorder associated with group A (PANDAS);
- (b) testing the fluid sample for at least one anti-streptococcal antibody;
- (c) testing the fluid sample for one or more autoantibodies that recognize an antigen from a protein selected from the group consisting of neuro-oncological ventral antigen 1 (Nova-1) and neuro oncological ventral antigen 2 (Nova-2), wherein at least one autoantibody of the one or more autoantibodies is anti-Ri;
- and
- (d) detecting in the fluid sample obtained from the same subject the one or more anti-streptococcal antibodies and the one or more autoantibodies by an immunofluorescence assay.
Dependencies are inferred from the claim text.