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US 11,768,150 B2Granted
Nanosecond-scale photothermal dynamic imaging
AssigneeTrustees of Boston University
InventorsJi-Xin Cheng, Lu Lan, Jiaze Yin
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Abstract
Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
Claims27
A method for performing photothermal dynamic imaging, the method comprising:
- scanning a sample to produce a plurality of raw photothermal dynamic signals;
- receiving the raw photothermal dynamic signals of the sample;
- generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise, the matched filtering performed by a comb-like passband in the frequency domain, wherein the comb-like passband includes at least one window with a center position colocalized at harmonic frequencies to reject non-modulated noise;
- performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain;
- identifying, using the at least one thermodynamic signal, a thermal decay difference between the sample and a water background of the sample;
- and
- removing, using the thermal decay difference, water-induced signals in the photothermal imaging of the sample.
4 more elements
A method for performing photothermal dynamic imaging, the method comprising:
- scanning a sample to produce a plurality of raw photothermal dynamic signals;
- receiving the raw photothermal dynamic signals of the sample;
- generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise, the matched filtering performed by a comb-like passband in the frequency domain, wherein the comb-like passband includes at least one window with a center position colocalized at harmonic frequencies to reject non-modulated noise;
- performing an inverse operation on the second signals to retrieve a at least one thermodynamic signal in a temporal domain;
- determining, using the at least one thermodynamic signal, a water background of the sample;
- determining a thermal decay difference between the water background and the sample;
- and
- suppressing, using the thermal decay difference, the water background in photothermal imaging of the sample.
5 more elements
A system for performing photothermal dynamic imaging, the system comprising:
- one or more computing device processors;
- and
- one or more computing device memories, coupled to the one or more computing device processors, the one or more computing device memories storing instructions executed by the one or more computing device processors, wherein the instructions are configured to:
- scan a sample to produce a plurality of raw photothermal dynamic signals;
- receive the raw photothermal dynamic signals of the sample;
- generate a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise, the matched filtering performed by a comb-like passband in the frequency domain, wherein the comb-like passband includes at least one window with a center position colocalized at harmonic frequencies to reject non-modulated noise;
- perform an inverse operation on the second signals to retrieve a at least one thermodynamic signal in a temporal domain;
- identify, using the at least one thermodynamic signal, a thermal decay difference between the sample and a water background of the sample;
- and
- remove, using the thermal decay difference, water-induced signals in the photothermal imaging of the sample.
7 more elements
A system for performing photothermal dynamic imaging, the system comprising
- one or more signal amplification devices for amplifying a plurality of raw photothermal dynamic signals;
- one or more signal acquisition devices coupled to the one or more signal amplification devices;
- one or more computing device processors coupled to the one or more signal acquisition devices;
- and
- one or more computing device memories, coupled to the one or more computing device processors, the one or more computing device memories storing instructions executed by the one or more computing device processors, wherein the instructions are configured to:
- scan a sample to produce the plurality of raw photothermal dynamic signals;
- receive the raw photothermal dynamic signals of the sample;
- generate a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise, the matched filtering performed by a comb-like passband in the frequency domain, wherein the comb-like passband includes at least one window with a center position colocalized at harmonic frequencies to reject non-modulated noise;
- perform an inverse operation on the second signals to retrieve a at least one thermodynamic signal in a temporal domain;
- determining, using the at least one thermodynamic signal, a water background of the sample;
- determining a thermal decay difference between the water background and the sample;
- and
- suppressing, using the thermal decay difference, the water background in photothermal imaging of the sample.
10 more elements
Dependencies are inferred from the claim text.