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US 11,767,562 B2Granted
Circulating serum cell-free DNA biomarkers and methods
AssigneeSt. John's University
InventorsSimon Geir Møller, Ketan Patil
Life of this patent
Estimating the term…
Abstract
Biomarkers and methods for identifying circulating serum-based cfDNA sequences. The cfDNA sequences (PDcRAs) can be used to differentiate patient's suffering from Parkinson's disease (PD) from non-PD patients.
Claims6
A method for treating Parkinson's disease in a human patient, comprising the steps of:
- obtaining a sample from said human patient, said sample being serum or plasma;
- and
- identifying differential levels of SEQ ID NOS:
- 10, 12, 13, 14, 23, 24, 27, 33, 34, 35, 55, 58, 62, 86, 89 and 93 within said sample compared to those of a healthy control;
- diagnosing the human patient as having Parkinson's disease based on the detection of differential levels of at least 2.066, 2.066, 2.568, 2.568, 3.927, 2.275, 0.663, 0.663, 0.663, 0.663, 1.327, 1.327, 1.327, 2.306, 1.842 and 2.471 fold, respectively, in the sample above that of the healthy control for each of SEQ ID NOS:
- 10, 12, 13, 14, 23, 24, 27, 33, 34, 35, 55, 58, 62, 86, 89 and 93;
- and
- administering L-dopa therapy to the human patient diagnosed as having Parkinson's disease.
5 more elements
Dependencies are inferred from the claim text.