US 11,767,561 B2 · Pattern recognition receptor expression as a measure of systemic health

Abstract

The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll-Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls.

Claims20

Dependent claims

A method for monitoring efficacy of a treatment on the systemic health of an animal in need thereof, the method comprising:

determining a first expression level of a first pattern recognition receptor in the animal at a first time point, wherein the first time point is prior to treatment;
determining a second expression level of the first pattern recognition receptor in the animal at a second time point subsequent to the first time point and after treatment;
and
comparing the first expression level to the second expression level;
wherein efficacy of the treatment is indicated by the first expression level being greater than the second expression level;
wherein the animal is afflicted with an oral health condition, and
wherein the treatment comprises therapy of the oral health condition.

4 more elements

Dependencies are inferred from the claim text.

Pattern recognition receptor expression as a measure of systemic health

Life of this patent

Pattern recognition receptor expression as a measure of systemic health

Life of this patent

Abstract

Claims20