Systems for producing cellular immunotherapeutics and methods of use thereof

A method for producing an immunotherapeutic product, the method comprising:

• providing cellular material associated with a disease from a patient in a first module of a fluidic system via a fluid inlet port of the first module;
• generating dendritic cells from monocytes of a patient sample in a second module of the fluidic system, the second module being positioned on a support of the fluidic system at an acute angle relative to a horizontal axis of the support when the fluidic system is in a functional orientation such that a fluid outlet port of the second module is retained above a fluid inlet port of the second module;
• flowing processed cellular material from the first module, via a fluid outlet port of the first module, and generated dendritic cells from the second module, via the fluid outlet port of the second module, into a third module of the system, the third module being separately coupled to and in fluidic communication with each of the first and second modules via a first inlet port fluidically coupled to the first module and a separate second inlet port fluidically coupled to the second module;
• and
• co-culturing the processed cellular material and generated dendritic cells in the third module to produce an immunotherapeutic product.