In vitro tissue plate

An in vitro tissue plate, comprising:

• a well plate including an array of wells, wherein the array of wells includes a plurality of tissue wells and one or more waste wells associated with the plurality of tissue wells;
• and
• a fluidic plate disposed on a bottom surface of the well plate, wherein the fluidic plate includes a plurality of fluid channels, wherein each tissue well is fluidly connected to an adjacent waste well by one of the plurality of fluid channels, wherein each tissue well of the plurality of tissue wells is connected to a respective fluid channel of the plurality of fluid channels by a plurality of tissue well pores, and wherein the plurality of tissue well pores are disposed at different locations along a length of the respective fluid channel.