Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
AssigneePraxis Precision Medicines, Inc.
InventorsKiran Reddy, Gabriel Martinez Botella, Andrew Mark Griffin, Brian Edward Marron, Carlos Loya
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Abstract
The present invention is directed to, in part, fused heteroaryl compounds of Formula (II-II): and compositions thereof, useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.
Claims16
A compound having Formula (II-II):
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- R1 is halo;
- R2 is C1-4 haloalkyl;
- R3 is H or C1-4 alkyl;
- R4 is H or C1-4 alkyl;
- or
- R3 and R4, taken together with the carbon atom to which they are attached, form a C3-6 carbocyclyl;
- R5 is C1-4 alkyl;
- and
- t is 0 or 1.
Dependencies are inferred from the claim text.